Interview with Paramita Venture: Penetrating Four Major Scientific Research Stages, Becoming a Leading Investor in DeSci Projects
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Interview with Paramita Venture: Penetrating Four Major Scientific Research Stages, Becoming a Leading Investor in DeSci Projects
Explore Paramita Venture's comprehensive DeSci investment landscape, Alpha incubation strategies, and future development trends.
Navigating Web3 tides with focused insightsAuthor: TechFlow
Let’s first turn the clock back one year:
Messari released its “Messari Theses 2024” report, expressing optimism toward Solana, AI + Crypto, and DeSci.
Looking back over the past year, the market has collectively witnessed the rise of the Solana ecosystem and the explosive growth of AI + Crypto—validating the credibility of Messari’s annual report as a top-tier crypto research institution.
As for DeSci, with endorsements from two heavyweight figures in the crypto industry—CZ and Vitalik—DeSci became the hottest sector in November 2024. However, as AI Agents and the Trump effect continue to capture market attention, community sentiment around DeSci appears to be polarizing.
Skeptics argue: DeSci is a fabricated narrative driven by celebrity promotions, briefly attracting community FOMO.
Firm believers counter: DeSci can genuinely bring transparency, democratization, and global collaboration to scientific research—not only representing the next frontier in crypto but also serving as a vital force in advancing human science.
At this moment of community debate, we were fortunate to have an in-depth conversation with Tykoo, Investment Director at Paramita Venture, and Eva, Investment Manager.
As a "mission-driven" investment firm that has been active in crypto since 2021, Paramita focuses on advancing innovation in decentralized information, decentralized science, and decentralized society to build a more open and secure digital future. The DeSci projects we now recognize—including Bioprotocol and VitaDAO—all received backing from Paramita Venture.
When the community wonders how Paramita Venture developed such sharp insight to become a leading investor in DeSci, Tykoo explains:
Our expertise lies more in strategic positioning across workflow stages. Our core focus is always on what problem a project is solving, not merely its research domain. Additionally, the founder is a critical investment criterion—their ability to interpret market narratives and manage product timing is essential.
Regarding community discussions about DeSci and Paramita Venture's long-term confidence in the sector, Eva candidly shares:
DeSci is an inherently long-cycle "scientific social movement." Even through short-term fluctuations, "science is valuable." Those who truly believe and commit will reap deeper value and returns.
In this article, let’s follow Tykoo and Eva’s insights to explore Paramita Venture’s full DeSci investment landscape, alpha-driven incubation strategies, and future development trends.
Exploring Paramita’s DeSci Investment Landscape Through Four Pillars of Research
TechFlow: We’re delighted to have this opportunity for an in-depth discussion. To begin, could you both introduce yourselves (feel free to share your educational background, relevant experience in the field, entrepreneurial journey, or how you joined Paramita Venture)?
Tykoo:
Hi everyone, I’m Tykoo. Previously, I worked at a Web2 dollar-denominated fund focusing on AI and Web3 sectors. Now at Paramita, I serve as an Investment Manager overseeing investments in decentralized AI and decentralized science. It’s great to discuss the DeSci space with you today.
Eva:
Hello, I’m Eva. I currently lead DeSci investments at Paramita and am also a co-founder of AuraSci, a community deeply supported by Paramita. Before joining Paramita, I worked at a Layer 2 blockchain team and launched NFT projects. Right now, I’m fully committed to DeSci and look forward to engaging with the community.
TechFlow: How would you summarize Paramita Venture’s mission or investment philosophy in one sentence?
Eva:
Paramita is a "mission-driven" investment firm focused on public protocols. We advocate building deep intersubjective consensus across stakeholders while minimizing reliance on single points of trust, to advance innovation in decentralized information, science, and society—ultimately shaping a more open and secure digital future.
TechFlow: Beyond recent endorsements from CZ and Vitalik, most people still don’t fully understand DeSci. Could you explain the advantages of DeSci compared to traditional research?
Tykoo:
For DeSci, I see the research process divided into four key stages:
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Topic Selection & Funding
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Research Collaboration
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Peer Review & Publishing
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IP Commercialization
DeSci aims to use blockchain technology to address pain points at each stage of traditional research.
On Topic Selection & Funding:
Traditional research is directed by a small group of funders, with lengthy approval cycles. DeSci opens channels for individual investors to support cutting-edge or niche topics and enables researchers to raise funds faster and more flexibly. At its core, DeSci efficiently answers a fundamental question in research:
“Who” decides “what” gets funded.
On Research Collaboration:
Beyond funding, the public can contribute various resources to research projects—such as dynamic data from hardware/DNA tests or computational/storage capacity. Using blockchain’s provenance capabilities, DeSci can track contributions, increase transparency in resource allocation, and reward contributors.
Among researchers, traditional science often suffers from data silos due to limited access to data, computing power, and storage. DeSci leverages on-chain records and smart contracts to track contributions, enhancing transparency and cross-institutional collaboration efficiency.
On Peer Review & Publishing:
Traditional peer review suffers from long timelines and lack of incentives. DeSci uses tokens to incentivize high-quality, timely reviews, reducing opacity and balancing reputation and financial rewards.
On IP Commercialization:
IP commercialization isn't limited to B2B models like patent licensing or technology transfer. Tokenization and decentralized referral mechanisms (similar to word-of-mouth marketing) can engage everyday consumers directly, enabling B2C monetization.
This allows research outcomes to reach end markets more directly, shortens intermediaries, and improves monetization efficiency.
Overall, compared to traditional research, DeSci offers more flexible and transparent solutions to key questions around “who sets research agendas, how resources are allocated, how to improve review efficiency and incentives, and how to maximize research impact.”
Of course, many challenges remain—such as whether individual investors are suitable for bearing the long duration and high risk of research investments; whether secondary market volatility negatively impacts research activities; whether token incentives compromise academic rigor and neutrality; and how to legally allocate IP ownership and link it to tokens across international collaborations. We are actively discussing these issues with ecosystem builders and developing solutions.
TechFlow: It’s understood that Paramita Venture established DeSci as a strategic focus during its brand upgrade in July 2023—well before DeSci entered mainstream awareness. The community is curious: how did your team identify this trend and make the decision?
Eva:
We’ve been following this space for nearly four years, though back then the concept of DeSci wasn’t clearly defined—most discussions revolved around Open Science.
Our fund partners have strong scientific backgrounds, so we’ve always valued academic IP. When we first encountered VitaDAO and learned about their IPNFT framework, we were immediately drawn to the idea and made our first move in the DeSci space.
At the same time, we founded and supported the AuraSci community to further explore the DeSci domain.
TechFlow: Could you walk us through Paramita Venture’s current investment portfolio—projects, achievements, and key metrics?
Tykoo:
As mentioned earlier, the research process can be broken down into four pillars: topic selection & funding, collaboration, peer review & publishing, and IP commercialization.
Paramita Venture’s investment strategy revolves around these four pillars:
In the topic selection & funding phase, we’ve invested in Bioprotocol and BioFoundry;
In the collaboration phase, our investments include Hetu Protocol, Hippocrat, Avinasi Labs, Data Lake, DeSci World, and BiohackerDAO;
In peer review & publishing, we’ve backed ResearchHub;
In IP commercialization, we’ve invested in Quantum Biology, VitaDAO, AthenaDAO, and ValleyDAO.
Clearly, Paramita Venture’s portfolio spans multiple well-known DeSci projects and covers the entire research lifecycle—from funding and collaboration to publication and commercialization.
From Screening Criteria to Outcome Measurement: Capturing the Next Alpha in DeSci
TechFlow: From VitaDAO researching longevity, to ValleyDAO focusing on climate and food security, to Athena DAO promoting women’s health—DeSci is flourishing across niches. As an institution, which types of DeSci products does Paramita Venture favor?
Tykoo:
This question assumes an investment approach based on research domains. However, our strength lies more in strategic positioning across workflow stages rather than diving deep into specific research fields.
Naturally, many new projects emerge—not just in climate and food security, but also quantum tech, materials science, and even space exploration. These aren’t necessarily our core expertise, but investing in them helps us understand DeSci better, deepen industry insights, and build key connections.
Therefore, beyond direct investments, we often participate as public donors to support ecosystem development.
Another important point: why has Bio become a representative sector in fundraising?
Because biotech and life sciences VC fundraising peaked in 2021 and has since slowed, hitting its lowest level since 2019 in 2024. Meanwhile, crypto is in a bull market—creating a cyclical capital mismatch. Bio bridges this gap perfectly.
But the same logic doesn’t apply to Space Technology, where massive capital is already flowing in. Each subfield has unique pain points. For example, AI as a research domain faces greater challenges in data collaboration—precisely where we prefer to focus.
So our core focus remains on what problem a project solves—not simply its research domain.
TechFlow: What criteria does Paramita Venture use when evaluating potential investments?
Tykoo:
Early on, I built a comprehensive evaluation framework with dozens of dimensions, each weighted differently.
But I later realized these dimensions and weights dynamically shift depending on project stage and external influences—mastering this adaptability became key.
The longer I stay in crypto’s primary market, the more I realize that for early-stage projects—especially in nascent fields like DeSci—the team is almost the only critical metric: their judgment of market narratives, product pacing, and even pivoting ability are all crucial.
Some founders are exceptionally energetic—like Paul from Bio, who has a strong ability to rally people around him.
RSC, founded by Brian Armstrong, gives off a solid, execution-focused vibe. Patrick often discusses how to get real researchers to use their product and solve actual problems. We’re also helping build ResearchHub China—feel free to connect.
TechFlow: What infrastructure do you think is needed to unlock DeSci’s breakout? How is Paramita Venture positioned here?
Tykoo:
First, it’s clear that our fund has always favored infrastructure-type products.
On this question, as previously discussed across the four stages, the biggest infrastructure needs lie in the second stage—collaboration.
Different industries present various infrastructure opportunities. That said, we don’t categorize DeSci investments strictly into infrastructure, middleware, and applications because the field is still too early—few application-layer products have emerged, so where would infrastructure demand come from?
In reality, I find many foundational components are broadly applicable across industries—such as storage and data. So we focus more on specific cases: what real-world problems they solve within their niche or research workflow. Often, these problems manifest as applications.
Real needs in research might include:
How to securely bring real-world research data on-chain and verify its authenticity—similar to what oracles do.
How to legally map real-world rights to on-chain assets—akin to RWA.
Other challenges include off-chain governance, attributing contributions among researchers, and contribution tracking. Traditional research often relies on simplistic algorithms using journal counts, impact factors, and citation numbers to assess reputation. In our portfolio, Hetu Protocol is working to solve this.
TechFlow: Research outcomes are notoriously hard to quantify, yet VCs are results-oriented. How does Paramita Venture navigate this challenge?
Tykoo:
Great question. Many DeSci projects attempt to quantify research output by introducing market-based mechanisms—because traditional research lacks quantifiability, it struggles to offer proper rewards.
TechFlow: A community question—there are now projects branding themselves as “community-driven DeSci funding platforms.” Compared to them, what advantages does Paramita Venture offer?
Tykoo:
I think that’s great—the market is free.
If a project can raise more funds in public markets, why should it accept VC capital? As long as funds flow to legitimate DeSci projects aligned with core values, we sometimes even encourage teams to test public markets. We can support them there too—no issue.
Paramita’s advantage lies in our institutional strength: higher risk tolerance, capacity for longer time horizons, superior asset discovery and risk pricing, and post-investment support that enables repricing.
Also, speaking of strengths, I must highlight my outstanding colleagues: Eva’s Aurasci scientist community, Frances’ Udaya developer community, Celine’s Moksha Labs incubator, and our partners’ early, generous, no-strings-attached donations to the DeSci community.
These efforts have helped us establish key footholds in both North American and Asian DeSci ecosystems.
From Meme to DeFi: Exploring the Future of DeSci and Crypto Integration
TechFlow: Pump Science made headlines, sparking broad community discussion on DeSci and Meme. How do you view the convergence of these two sectors?
Tykoo:
I believe every domain has meme-like attributes—some commonalities, some differences.
The commonality is that memes in DeSci still represent exchanges and competition of traffic and capital across domains: Web2 tells the story of memes bringing visibility to niche sciences, spreading knowledge, attracting funding, and advancing research; Web3 profits from the legitimacy of scientists boosting meme trading volume. If DeSci is seen as a scammy fundraising tool, its credibility could suffer severely.
If someone loses money on a DeSci-themed meme coin and then doubts the entire sector, that’s the last thing we, as ecosystem builders, want. The core issue with memes is how to punish bad actors—this remains an open and important design challenge.
The difference is that DeSci narratives require domain-specific expertise. While meme traders love finding angles, DeSci meme angles are harder to grasp due to technical complexity. Some may take large positions without truly understanding—this imbalance risks harming real scientific progress.
Long-term, the market will correct itself.
Another difference is higher market tolerance for certain DeSci memes, similar to lottery logic: losing feels like contributing to science.
TechFlow: Despite its grand vision, DeSci remains abstract for average users. Market attention naturally gravitates toward products with clear financial returns, and crypto economics remains largely built on DeFi. Do you think deeper integration between DeSci and DeFi could generate more interest in the sector?
Tykoo:
Absolutely. Not just DeSci and DeFi, but even traditional research combined with traditional finance can attract more attention to science.
Once research gains financial attributes and a speculative market forms around it, profit-seeking participants will inevitably join.
TechFlow: Indeed, DeSci is still in its infancy—early movers face both opportunities and challenges. What obstacles do you see in DeSci’s current development, and how is Paramita Venture addressing them?
Tykoo:
I believe the entire DeSci space currently faces an investor expectation management problem. If project teams intentionally or unintentionally communicate unclear messages, investors won’t know exactly what they’re buying—lacking sufficient understanding of investment duration, risk, or underlying rights—which harms the market.
Science requires patience, but markets crave constant news to drive sentiment. Hence, more transparent formats—like live streams or prediction markets—may gain traction. Such projects resemble science communication more than actual research.
Additionally, there’s a lack of effective oversight and punishment mechanisms for bad market actors.
Moreover, like many RWA and Oracle products, DeSci involves real-world rights and information flows, requiring deeper protocol-level coordination.
Industry Trend Insights and Future Roadmap
TechFlow: Social media discussions on DeSci show extreme polarization. As long-term advocates in the DeSci space, how do you view community skepticism? And what enables you and your team to stay committed through FUD?
Eva:
Doubt and debate on social media actually prove that DeSci—an emerging concept—is gaining broader attention and discussion. As “long-term warriors” in DeSci, we welcome and understand these critiques.
Any social movement aiming to transform traditional systems will inevitably face differing views or even fierce opposition—because it disrupts the status quo and introduces new possibilities.
Our steadfast commitment to DeSci despite FUD stems from several core beliefs and observations:
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Long-termism: From Short Cycles to Grand Narratives
DeSci is a social movement leveraging blockchain and decentralization to reshape research funding and collaboration. Unlike traditional science, such transformation cannot happen in one or two years—it demands a long-term narrative and sustained practice.
From our early involvement in the DeSci ecosystem, even through minor cycle fluctuations, we’ve seen continuous iteration in community, technology, and ideology. This shared belief in scientific value and decentralization allows us to maintain a long-term vision beyond fleeting market hype.
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Ongoing Evolution: Emergence of New Models and Integrations
This wave has brought innovative combinations—such as merging meme culture with the DeScAI concept, integrating decentralized open collaboration with AI’s powerful data processing and predictive capabilities.
These explorations expand DeSci’s application scenarios and inject greater creativity into future research models. When DeSci’s decentralization deeply integrates with AI’s cutting-edge tech, it may form an even more disruptive research ecosystem.
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The Inherent Value of Science
Most importantly, we firmly believe “science is valuable.”
No matter how market sentiment shifts, the value of scientific research remains unchanged. DeSci’s significance lies in providing science with a more open, transparent, and incentive-rich environment. If this environment nurtures breakthroughs—such as accelerating drug discovery via AI-driven data analysis, or enabling grassroots research projects to thrive through decentralized funding—then DeSci’s long-term value will be fully validated.
This is an inherently long-cycle “scientific social movement,” requiring time, conviction, and collective wisdom to cultivate and witness. Skepticism helps the DeSci community reflect and iterate, while those who truly believe and invest in the ecosystem will gain deeper value and returns through this evolving journey.
TechFlow: Final question—please share Paramita Venture’s key priorities for 2025, so the community can better anticipate upcoming milestones.
Eva:
In 2025, Paramita Venture will continue focusing on DeSci and AI, exploring more innovative intersections.
We aim to strengthen existing investments and research outcomes while fostering greater interdisciplinary and cross-community collaboration, injecting fresh imagination and creativity into the ecosystem.
Simultaneously, we’ll further refine our post-investment support system—from technical empowerment and funding continuity to community co-building—to provide sustained support for research and blockchain projects that solve real problems and deliver long-term value.
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