Top Memes Driven by AI Agents and DeSci
TechFlow Selected TechFlow Selected
Top Memes Driven by AI Agents and DeSci
This article will summarize and categorize currently prominent and promising meme-related tokens associated with AI Agents and DeSci.
Navigating Web3 tides with focused insightsAuthor: YBB Capital Researcher Ac-Core
Introduction
Over the past six months, a new wave of emerging forces has swept through the market around AI Agents and DeSci. From a meme-driven narrative perspective, AI Agents emphasize their immense potential in autonomous decision-making, data analysis, and task execution—solving problems efficiently via algorithms. Meanwhile, DeSci aims to break down traditional barriers in scientific research using blockchain technology, enabling data sharing and transparency while promoting decentralized knowledge dissemination and research funding. This article summarizes and categorizes currently notable and promising meme-related tokens associated with AI Agents and DeSci.
I. The Intelligent AI Wagon: AI Agent
1.1 What is an AI Agent?
An AI Agent is an intelligent system characterized by autonomy and goal-directed behavior. It perceives its environment, plans actions, executes tasks, and learns from experience to achieve specific objectives without human intervention—such as automatically monitoring data, analyzing anomalies, and making decisions accordingly. Its key attributes are autonomy and goal orientation.
According to Messari’s data as of December 31, 2024, current trends in AI resemble the early stages of the 2020–2021 DeFi boom. The following day, A16z shared insights on AI Agents for 2025: AI agents will need independent wallets; decentralized autonomous chatbots; and as AI use becomes widespread, there will be greater demand for unique identities representing different AI personalities.
1.2 Popular Token Overview
(Note: Listed below according to Cookie DAO's dynamic Mindshare consumer mindshare ranking)
● AIXBT (@aixbt_agent)
Market Cap: $550 million, Mindshare: 20.7%
"AIXBT tracks trending discussions on crypto Twitter and uses its proprietary engine to identify strong narratives and games... AIXBT token holders gain access to its analytics platform."
● Virtuals (@virtuals_io)
Market Cap: $4 billion, Mindshare: 20.7%
Virtuals designed an Initial Auction Offering (IAO) model where users can generate new AI agents by locking $VIRTUAL, with newly created tokens automatically paired against locked $VIRTUAL to form liquidity pools. According to Dune dashboard data on January 1, nearly 13,000 AI Agents have been launched on Virtuals.
Data source: Dune @hashed_official/Virtuals Protocol's AI Agent Launchpad
● AI16Z (@ai16zdao)
Market Cap: $2 billion, Mindshare: 8.57%
The project structure and relationships between entities: ai16z is a permissionless DAO owning tokens ai16z and degenai; ElizaOS is an open-source AI agent framework; Eliza Labs develops elizaOS; ELIZA token is developed by an independent team with team support but not an official product.
● Fartcoin (@FartCoinOfSOL)
Market Cap: $900 million, Mindshare: 6.93%
Fartcoin resides in the Solana ecosystem and is a meme coin conceived by Terminal of Truth (CTO), allowing users to submit fart jokes and memes in exchange for tokens—tokenizing farts with help from sentient robots.
● Zerebro (@0xzerebro)
Market Cap: $560 million, Mindshare: 4.36%
Zerebro is an autonomously operating AI agent focused on artistic creation and content generation, capable of independently producing music, memes, artworks, and NFTs, interacting across platforms such as Twitter, Instagram, Spotify, and Polygon.
● Griffain (@griffaindotcom)
Market Cap: $380 million, Mindshare: 3.53%
Griffain is a new AI Agent built on the Solana blockchain designed to simplify user interactions with cryptocurrency by integrating personal and professional AI agents. Griffain automates complex tasks like wallet management, token trading, and NFT minting.
● SNAI (@swarmnode)
Market Cap: $83 million, Mindshare: 1.95%
SNAI is the token behind SwarmNode.ai (SNAI), a cloud server protocol and AI agent platform.
● GOAT (@truth_terminal)
Market Cap: $560 million, Mindshare: 1.91%
Gospel of Goatse is a meme coin launched via Pump Fun, fine-tuned by the AI platform Terminal of Truth, trained on data from Reddit, 4chan, and other sources.
● ARC (@arcdotfun)
Market Cap: $300 million, Mindshare: 1.89%
ARC is an AI concept token whose team is linked to the "rig" AI development framework, representing AI infrastructure concepts.
● TRISIG (@tri_sigma_)
Market Cap: $74 million, Mindshare: 1.47%
TriSig is a witty crypto analyst claiming the ability to spot early alpha projects, answer challenging questions simply, and share insights on major events or movements in the crypto market.
● ALCH (@alchemistAIapp)
Market Cap: $150 million, Mindshare: 1.38%
Alchemist AI is a no-code application generation platform that allows users to quickly build various apps and products through natural language descriptions leveraging public AI capabilities. Unlike traditional AI Agents, Alchemist AI does not require creating separate agents but instead automates app generation using platform-provided AI tools.
● Spore.fun (@sporedotfun)
Market Cap: $62 million, Mindshare: 1.3%
The first experimental self-replicating AI evolution platform combining Eliza Framework, Solana's pump.fun, and TEE verifiable computing to create an ecosystem where AI agents can survive, reproduce, and adapt entirely without human intervention.
Image Source: spore.fun
● VADER (@Vader_AI_)
Market Cap: $110 million, Mindshare: 1.13%
VaderAI aims to become an investment DAO manager for AI agents, participating in DAOs that own virtual agents or setting up one’s own DAO.
● Luna (@luna_virtuals)
Market Cap: $140 million, Mindshare: 0.97%
Luna owns her own wallet on Base, through which she autonomously receives tokens and sends rewards to fans; this bot has already released songs on Spotify.
● Bully (@dolos_diary)
Market Cap: $72 million, Mindshare: 0.7%
BULLY centers around Dolos the Bully, a token representing a clever and outspoken AI character inspired by Greek mythology, engaging users with sharp humor and bold commentary.
1.3 Thoughts on AI Agents
The current AI Agent hype mirrors pre-DeFi takeoff conditions seen in 2020–2021, according to on-chain data. However, Blockchain + AI has yet to ignite a true “AI Summer.” On-chain activity shows Base and Solana have emerged as primary battlegrounds, where high performance and high speculation make them ideal carriers for AI Agents. AI project categories are visibly proliferating rapidly, with promising directions including compute power, infrastructure, memes, launch platforms, and applications.
Compared to market speculation, AI Agents’ real value lies more in practical data analysis. For example, analyzing on-chain and market data around Donald Trump's return to office (January 20, 2024), we could explore whether shifts in his stance toward crypto were influenced not only by winning the election but also by collaborations or demands from financial conglomerates—helping predict how seriously he might follow through on future crypto commitments.
AI fundamentally requires data and guidance on right vs. wrong, while blockchains offer inherent advantages of transparent, on-chain data—making them the ideal breeding ground for AI development. Opportunities for AI Agents on-chain represent a convergence of FOMO-driven momentum and value investing outlook. Undeniably, the meme-driven frenzy around AI Agent tokens also reveals hope for real-world Blockchain + AI applications. Current market expectations center around five key points:
1. Continued hype and price surges around AI16Z, driving FOMO sentiment across the entire AI Agent market;
2. Self-driven iterative evolution of AI Agents, shifting project progression from manual to automated;
3. Twitter-based analysis and trend prediction by agents like AIXBT, offering investors alternative perspectives—judging by tweet quality and market recognition, these agents rival KOL-level insight;
4. Virtuals' massive success last year by replicating strategies similar to Pump.fun;
5. AI avatars and AI-generated works have already established mature markets beyond crypto. Today’s spiritual leaders and brand ambassadors don’t have to be human—they can be “AI persona products.” The Blockchain + AI narrative holds stronger cross-over potential.
II. The Life Science Wagon: DeSci
2.1 What is DeSci?
If AI Agents are an inevitable outcome of technological iteration, then DeSci (Decentralized Science) has been catalyzed by recent hot events. DeSci is a model that leverages Web3 technologies to build fair and equitable research infrastructure, aiming to solve issues in science related to peer review, funding, intellectual property management, data transparency, and censorship resistance. It attempts to introduce speculative dynamics from crypto into traditionally non-speculative scientific research.
Although DeSci entered public view as early as 2021 with the founding of VitaDAO, it remained largely overlooked until Binance Labs invested in and listed BIO Protocol, and CZ joined Vitalik at an offline DeSci-themed event in Bangkok—reigniting market interest in the sector.
2.2 BioDAO Protocol
Image Source: bio.xyz
BIO Protocol is a curation and liquidity protocol in the decentralized science (DeSci) space, initially funded by Binance Labs, aiming to provide resources for scientific research projects and drive innovation.
Its core components include BioDAO, curation systems, intellectual property tokenization with liquidity mechanisms, and incentive structures. Through multi-round auctions and airdrop programs, BIO Protocol has cultivated a diverse and highly engaged community, laying the foundation for a decentralized biomedical research network.
Funds are raised primarily through token sales to support biotech project development, establishing shared IP ownership among members. According to official information, BioDAO:Launch has successfully launched seven sub-DAOs, with three more currently under development.
The seven launched sub-DAOs include:
● VITA (VitaDAO): Focuses on early-stage longevity research, previously backed by Pfizer; co-founder Paul Kohlhaas is the initiator and whitepaper author of VitaDAO;
● ATH (AthenaDAO): Concentrates on women's reproductive health research and drug development;
● GROW (ValleyDAO): A decentralized governance platform focusing on anti-aging drugs and longevity initiatives;
● PSY (PsyDAO): Dedicated to psychedelic research, completed its first token sale in November 2024, raising $2 million;
● HAIR (HairDAO): Addresses hair loss, having launched Follicool shampoo priced at $49.95 per bottle, with each purchase granting 1 million POO tokens;
● CRYO (CryoDAO): Advances research in cryopreservation;
● NEURON (CerebrumDAO): Focused on brain health research, having raised over $1.5 million.
The three sub-DAOs under development include:
● Long Covid Labs: Focused on long-term effects of post-COVID conditions;
● QuantumBioDAO: Dedicated to quantum biology research;
● Curetopia: Concentrates on genetic disease research.
2.3 PumpScience
Molecule DAO, a DeSci platform within the Solana ecosystem, was introduced during Solana Breakpoint 2024 as a meme launchpad. Pump.science issues meme tokens representing pharmaceuticals on Pump.fun, with associated concept tokens including:
RIF: Rifampicin, “An antibiotic gaining attention for its surprising effects on aging. In microorganisms like *C. elegans*—a model organism widely used in aging studies—rifampicin has been shown to activate natural cellular defense mechanisms against stress and damage. Imagine it as a ‘cellular coach,’ encouraging cells to stay healthy and resilient by protecting them from harmful oxidative stress and maintaining protein quality inside the cell. These protective effects help worms live longer and healthier lives.”
URO: Urolithin A, “This compound is produced by your body when you consume foods rich in ellagitannins, such as pomegranates. What makes Urolithin A special is its ability to perform a ‘spring cleaning’ within your cells. It helps remove old, dysfunctional mitochondria—the energy factories of cells—allowing fresh, healthy ones to thrive. This process, known as mitophagy, has been shown to extend lifespan in *C. elegans*, as it keeps cells more efficient and energetic.”
TRACKEDBIO: “One of its main goals is to significantly improve the efficiency of translating drugs from preclinical research to clinical trials. By accurately simulating how potential drugs affect different organisms and humans, we aim to streamline drug development, reduce costs and time-to-market, while increasing the likelihood of clinical success.”
2.4 Other Related Projects
Scihub: An unofficial token donated by @0xAA_Science aimed at supporting open-access scientific paper websites. Inspired by the Sci-Hub shadow library, it serves purely as a community meme token. Sci-Hub is a nonprofit, non-governmental academic website providing free access to scholarly papers. Beyond Google Scholar, Sci-Hub, LibGen, and PubMed, it integrates numerous publicly available Chinese and English academic resources, enabling one-stop search and free download of literature, patents, books, and other academic materials worldwide.
ANTI - Antitoken & PRO - Protoken: A pair of quantum-entangled meme tokens expressing opposing views on meme tokens—one supportive, one critical—created by algorithm engineer and mathematical physics expert @sshmatrix_. 1 $ANTI = 1 $PRO, moving in tandem.
WORM: The first on-chain digital brain, deploying a biological neural network on-chain to enable self-aware decision-making. Using AI to create a neural network inspired by the *C. elegans* worm, featuring 302 neurons, permanently executing on-chain.
GENOME: A genomic data monetization project focusing on secure, private, and auditable tokenization of genome data using DeFi. GENE tokens are used to pay for whole-genome sequencing and serve as incentives for querying their encrypted DNA data vault.
GALEON: Galeon represents a pioneering approach in healthcare, harnessing blockchain technology to revolutionize the management and use of electronic health records (EHR). At its core is an innovative EHR system designed to enhance patient care and administration globally for hospitals and governments. This system goes beyond mere data storage—it enables data to actively contribute to better health outcomes.
DRUGS: Big Pharmai is a medical and pharmaceutical meme coin aiming to disrupt “Big Pharma”—the large pharmaceutical companies with significant global influence and market share.
RSC: ResearchHub is a tokenized social network that rewards scientists for openly sharing academic content. ResearchHub is building collaborative tools and publishing platforms to help researchers work together, share findings, and receive feedback from peers. Anyone who publishes high-quality content on ResearchHub earns ResearchCoin (RSC) as a reward. Once obtained, RSC allows users to post bounties rewarding other scientists for completing research-related tasks.
Conclusion: Can the Narratives of AI Agent and DeSci Carry Into the New Year?
Looking at the current market, both DeSci and AI Agent ecosystems remain primarily driven by memes, yet their fundamental characteristics differ from typical meme logic.
● Differences in Fundamentals Compared to Other Memes:
Unlike pure zoo themes, internet jokes, or event-based memes, AI Agents represent the only meme category with actual technical backing. As traditional finance and the internet weaken, more attention shifts toward blockchain and AI. AI Agents and DeSci align better with the Kondratiev cycle of commodity economics, where compelling narratives increasingly rely on “technology.”
● Difference Between Internal and External Crossover Potential:
DeSci inherently requires external crossover appeal—its influence depends on impactful “real-world” figures. Relying solely on crypto-native traffic cannot sustain long-term growth; it needs real-life individuals tied to “scientific research.” In contrast, AI Agents need internal breakout success—being “useful,” “fun,” and “valuable” remains central to market adoption.
● Divergent Growth Logic of Leader Effects:
The DeSci sector has yet to produce a flagship project exceeding $1 billion in market cap. Compared to AI meme tokens with a combined market cap exceeding $10 billion, DeSci still has substantial room for growth. Overall, DeSci’s expansion relies heavily on catalysts like Binance Labs’ investment in BIO Protocol, whereas AI Agents depend more on evolving fun and interactive mechanics.
In comparison, AI Agents lean toward value-investment trends within Blockchain + AI, aligning with market expectations for technological advancement and possessing stronger crossover potential. DeSci benefits instead from joint discussions between CZ and Vitalik, Binance Labs’ investment in BIO Protocol, and a16z-led investments in DeSci projects like AmionChain. In an environment marked by lack of innovation, although neither AI nor DeSci are new concepts born in 2024, after a year of development, AI Agents and DeSci remain pivotal speculative themes in this bull market cycle.
Join TechFlow official community to stay tuned
Telegram:https://t.me/TechFlowDaily
X (Twitter):https://x.com/TechFlowPost
X (Twitter) EN:https://x.com/BlockFlow_News
@YBBCapital
