DeSci Narrative Reignites: With Coinbase Founder Joining, Which Projects Are Worth Watching?
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DeSci Narrative Reignites: With Coinbase Founder Joining, Which Projects Are Worth Watching?
DeSci and the so-called "longevity" concept have become new focal points, bringing a long-dormant narrative back into the spotlight.
Navigating Web3 tides with focused insightsBy TechFlow
Recently, the hashtag #DeSci has been repeatedly appearing in crypto Twitter discussions.
What is DeSci? In fact, it’s not a new concept.
DeSci is an abbreviation for "Decentralized Science." In practice, it leverages cryptocurrencies and smart contracts to fund research, brings transparency to scientific publishing and peer review, and makes research results accessible to a broader public—thus promoting knowledge sharing and scientific advancement.
Last year, Open Science NFTs were launched, with research teams raising funds through NFT auctions.
More recently, CZ reignited interest in DeSci with a post expressing his personal research interests:
Following this, DeSci and the so-called "longevity" concept became new focal points, bringing a long-dormant narrative back into the spotlight.
Unlike most Web3 projects that focus on virtual economies, DeSci touches real-world scientific development—such as biotechnology, pharmaceuticals, and environmental science—offering positive and tangible social value.
As a result, related tokens and projects have gradually gained recognition and collectively seen price increases of at least 50% or more.
Narratives in the crypto world shift extremely fast, and each may only have a short window of opportunity. Against the backdrop of renewed interest in DeSci, which potential projects are worth early attention?
1. Data Lake: A Patient Medical Data Donation Platform
Twitter: @DataLakeToken
Website: https://data-lake.co/
Token: $lake
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Market Cap: $2.6M (CMC data)
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FDV: $51M
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30-day change: +360%
Project Overview:
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Data Lake builds a blockchain-based global medical data donation system to support medical research and AI.
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Using Polygon and its token ($LAKE), it creates a system connecting patients and researchers who need medical data, supporting the search for disease treatments and new therapies, improving healthcare and patient outcomes.
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Data Lake can obtain access to donors’ medical records from healthcare providers, anonymize the data, and potentially make it available to researchers, while allowing hospitals and data donors to share in the economic benefits of medical data.
Current Highlights:
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Staking pool is now open—depositing $lake offers up to 422% APR returns
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Token utility initiatives are emerging, but yields are expected to decline as participation grows
2. ResearchHub: A Platform Founded by Coinbase’s Founder to Transform Traditional Scientific Publishing
Twitter: @ResearchHub
Website: https://www.researchhub.com/
Token: $RSC
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Market Cap: $30M
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FDV: $564M
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30-day change: +3660%
Project Overview:
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ResearchHub is a tool designed to support open publication and discussion of scientific research, aiming to overcome the low incentives inherent in traditional scientific funding and publishing models.
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Founded by Coinbase co-founder Brian Armstrong, the project secured $5 million in Series A funding on June 15 this year.
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ResearchHub replaces traditional journal publishing with a centralized hub, enabling simplified and open publication of scientific or academic content directly within the platform. This eliminates gatekeeping processes and accelerates information dissemination, with peer review conducted post-publication.
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To complement these features, users on ResearchHub can earn ResearchCoin ($RSC) rewards through the following activities:
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Sharing research paper PDFs (provided no copyright is violated)
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Commenting on and discussing scientific research
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Peer reviewing scientific papers
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Receiving RSC tips from other users
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Developing open-source features
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Current Highlights:
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On December 17, the project will host an event (Private Event) in Taipei during Blockchain Week, together with Sora Ventures, possibly revealing further updates
3. GenomesDAO: A Secure Vault for Personal Genetic Sequencing Data
Twitter: @GenomesDAO
Website: https://genomes.io/
Token: $GENE
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Market Cap: $3.7M
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FDV: $30.3M
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30-day change: +227%
Project Overview:
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GenomesDAO is a biotech DAO focused on securely, privately, and auditably monetizing genomic data using DeFi.
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For individuals: provides clinical-grade whole genome sequencing, personalized genomic reports based on this data, and secure storage within a personal DNA vault.
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For organizations: offers DNA vault technology to build secure, participant-owned genomic databases.
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For researchers: enables easy access to high-quality genomic datasets to understand disease causes and develop new drugs.
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$GENE tokens are used to pay for whole genome sequencing and serve as incentives for querying their encrypted DNA data vaults.
Current Highlights:
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Per DAO voting, the project has approved allocating 25 million GENE tokens to provide liquidity for Uni V3 on the Ethereum mainnet.
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This move could significantly improve the liquidity of GENE, which currently has a relatively small market cap.
4. VitaDAO: Crowdfunding Community Funds for Longevity Research
Twitter: @vita_dao
Website: https://www.vitadao.com/
Token: $VITA
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Market Cap: $34M
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FDV: $250M
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30-day change: +88%
Project Overview:
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VitaDAO is a community governed by $VITA holders, focused on funding early-stage longevity research.
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It has already funded over 20 research projects, totaling more than $6 million.
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Projects include research on age-related diseases and the discovery of potential new therapies, spanning from basic research to preclinical stages.
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$VITA holders vote on research funding decisions, overall strategy, financial management, and other governance activities aimed at improving DAO operations.
5. HairDAO: Focused on Hair Loss Research, with a Strong Meme Vibe
Twitter: @HairDAO_
Website: https://about.hairdao.xyz/
Token: $HAIR
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Market Cap and FDV: No consistent calculation available
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30-day change: +92.6%
Project Overview:
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HairDAO is an open-source investment and operating organization dedicated to hair loss treatment, aiming to democratize research and development in this area.
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It funds early-stage research and companies focused on understanding and treating hair loss.
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HairDAO encourages people with diverse skills—technical or domain-specific—to join its working groups.
- The $HAIR token rewards contributors helping solve hair loss. Users can earn $HAIR by uploading their anonymous, encrypted genomic data.
Current Highlights:
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Despite its scientific focus, HairDAO's website and Twitter content are far from serious in tone and design—its website even resembles the humorous aesthetic of silent films.
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Among the otherwise serious and research-focused projects in the DeSci space, this "hair loss" theme feels more like a meme, complete with a barber shop 💈 emoji in its Twitter handle.
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Given its unclear market valuation and the current DeSci hype, $HAIR is best approached as a meme coin.
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